Dr. Ana Daugherty began an affiliation with the on-going longitudinal study in 2008 and has been leading the study since 2022.

Dr. Naftali Raz initiated the longitudinal study in 2001 and remains co-Principal Investigator (additional collaborative publications associated with the study).


Complete List of Dr. Ana Daugherty's Published Work


Peer-Reviewed Journal Articles (mentored student author name underlined)


Levanovich P, Daugherty AM, Komnenov D, Rossi N. 2022. Dietary fructose and high salt in young male Sprague Dawley rats induces salt-sensitive changes in renal function in later life. Physio Reports. [In press].

Delgorio PL, Hiscox LV, Daugherty AM, Sanjana F, McIlvain G, Pohlig RT, McGarry MDJ, Martens CR, Schwarb H, Johnson CL. 2022. Structure-function dissociations of human hippocampal subfield stiffness and memory performance. J Neurosci. [In press].

Edwards, E., Daugherty, A.M., & Fritz, N. 2022. Examining the influence of cognition on the relation between backward walking and falls in persons with multiple sclerosis. Int J of MS Care. [In press].


Venkatesh A, Daugherty AM, Bennet IJ. 2021. Neuroimaging measures of iron and gliosis explain memory performance in aging. Human Brain Mapping. [Epub 2021 Sep 14]. doi: 10.1002/hbm.25652

Arble EA, Shankar S, Steinert SW, Daugherty AM. 2021. Mental health in residential healthcare workers during the COVID-19pPandemic: The moderating role of selfobject needs. Frontiers Psychiatry. [In press]. doi: 10.3389/fpsyt.2021.596618

Daugherty AM. 2021. Hypertension-related risk for dementia: A summary review with future directions. Sem Cell Dev Bio. [Epub 12 Mar 2021].

Homayouni R, Yu Q, Ramesh S, Daugherty AM, Ofen N. 2021. Test-retest reliability of hippocampal subfield volumes in a developmental sample: Implications for longitudinal developmental studies. J Neurosci Res. [Epub 22 Mar 2021].

Rajesh A, Noice T, Noice H, Jahn, A, Daugherty AM, Heller W, Kramer AF. 2021. Can a theatre acting intervention enhance interference control in older adults? A brain-behavior investigation. Front Aging Neurosci.  [Epub 18 Mar 2021].


Kairys A, Daugherty AM, Kavic V, Shair S, Persad C, Heidebrink J, Bhaumik A, Giordani B. 2021. Lap-top administered NIH Toolbox and Cogstate Brief Battery in community-dwelling Black adults: Unexpected pattern of cognitive performance between MCI and healthy controls. JINS. [Epub 23 Mar 2021]. doi: 10.1017/S135561772100028X


Steinert SW, Daugherty AM, Shankar S, Schwarb HD, Cerjanic A, Sutton BP, Arble EA. 2021. A performance-based measure of emotion response control: A preliminary MRI study. Scand J Psychol. [Epub 6 Jan 2021]. doi: 10.1111/sjop.12705


Kavcic V, Daugherty AM, Giordani B. 2021. Post-task modulation of resting state EEG differentiates MCI patients from healthy controls. Alzheimers Dement: DADM. 13 (1): e12153. [Epub 20 Feb 2021]. doi: 10.1002/dad2.12153.


Delgorio PL, Hiscox LV, Daugherty AM, Sanjana F, Pohlig RT, Eliison JM, Martens CR, Schwarb H, McGarry MDJ, Johnson CL. 2021. Effect of aging on the viscoelastic properties of hippocampal subfields assessed with high-resolution MR elastography. Cer Cor. [Epub 18 Jan 2021]. doi: 10.1093/cercor/bhaa388


Daugherty AM, Chopra T, Korzeniewski S, Levy P. 2020. COVID-19 as a Risk Factor for Alzheimer's Disease and Related Dementia: A Perspective for Future Clinical Research. Psych Res. 294: 113557. [Epub 4 Nov 2020]. doi: 10.1016.j.psychres.2020.113557.


Wisse LEM, Chetelat G, Daugherty AM, De Flores R, LaJoie R, Mueller S, Shinohara R, Stark C, Wang L, Yushkevich P, Olsen R, Carr V. 2020. Hippocampal subfield volumetry from structural isotropic 1 mm3 MRI scans: A note of caution. Hum Brain Mapp. 42 (2): 539-550. [Epub 15 Oct 2020]. doi: 10.1002/hbm.25234.


Arble EP, Shankar S, Steinert SW, Daugherty AM. 2020. Mental health and emotional resiliency in Detroit nursing home workers during the COVID-19 pandemic. J Nursing Home Research Sciences. 6: 89. [Epub 2020 Oct 7]. doi: 10.14283/jnhrs.2020.23.


Foster CM, Kennedy KM, Daugherty AM, Rodrigue KM. 2020. Contribution of iron and Aβ differences in entorhinal and hippocampal subfield volume. Neurol. 95 (18): e2586-e2594. [Epub 2020 Sept 16]. doi: 10.1212/WNL.0000000000010868.


Edwards EM, Daugherty AM, Nitta M, Atalla M, Fritz NE. 2020. Backward walking sensitively detects fallers in persons with multiple sclerosis. Multiple Sclerosis and Related Disorders. 45: 102390. [Epub 2020 Jul 10]. doi: 10.1016/j.msard.2020.102390.


Daugherty AM, Arble EP. 2020. Prevalence of Mental Health Symptoms in Residential Healthcare Workers in Michigan during the COVID-19 Pandemic. Psych Res. 291: 113266. [Epub 2020 Jun 30]. doi: 10.1016/j.psychres.2020.113266.


Golja K, Daugherty AM, Kavcic V. 2020. Cognitive reserve and depression predict subjective reports of successful aging. Arch Geron & Ger. 90, 104137. [Epub 2020 Jun 6]. doi: 10.1016/j.archger.2020.104137.


Tang L, Pruitt PJ, Yu Q, Homayouni R, Daugherty AM, Damoiseaux JS, Ofen N. 2020. Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting Memory Development. Frontiers Human Neuroscience. [Epub 2020 Jun 5]. doi: 10.3389/fnhum.2020.00204.


Daugherty AM, Schwarb HD, McGarry MDJ, Johnson CL, Cohen NJ. 2020. MR elastography of human hippocampal subfields: CA3-dentate gyrus viscoelasticity predicts relational memory accuracy. J Cog Neuro. 32 (9): 1704-1713. [Epub 2020 July 31]. doi: 10.1162/jocn_a_01574


Rvuolo Grasser L, Burghardt P, Daugherty AM, Amisadri A, Javanbakht A. 2020. Inflammation and trauma-related psychopathology in Syrian and Iraqi refugees. Behav Sci. 10 (4): 75. [Epub 2020 Apr 7]. doi: 10.3390/jbs10040075.


Rajesh A, Daugherty AM, Jain S, Henry D, Barbey AK, Rubin RD. 2020. Comorbid conditions differentiate rehabilitation profiles in traumatic versus non-traumatic brain injury: A retrospective analysis using a medical database. J Head Trauma Rehabilitation. 35 (6): E524-E534. [Epub 2020 May 27]. doi: 10/1097/HTR.0000000000000578


Rodrigue KM, Daugherty AM, Foster CM, Kennedy KM. 2020. Striatal iron accumulation is linked to reduced fronto-striatal brain function under working memory load. NeuroImage. 210: 116544. [Epub 2020 Jan 20]. doi: 10.1016/j.neuroimage.2020.116544.


Arble E, Steinert SW, Daugherty AM. 2020. The application of the Rorschach inkblot test in the study of neural and cognitive aging. Rorschachania. 41: 1-18. [Epub 2020 Apr 29]. doi: 10.1027/1192-5604/a000120


Daugherty AM, Sutton BP, Hillman CH, Kramer AF, Cohen NJ, Barbey AK. 2020. Individual differences in the neurobiology of fluid intelligence predict responsiveness to training: Evidence from a comprehensive cognitive, mindfulness meditation, and aerobic exercise intervention. Trends Neurosci. Educ. 18: 100123. [Epub 2019 Nov 5]. doi: 10.1016/j.tine.2019.100123


Zwilling CE, Daugherty AM, Hillman CH, Kramer AF, Cohen NJ, Barbey AK. 2019. Enhanced decision-making through multimodal training. NPJ Science of Learning. 4: 11. [Epub 2019 Aug 5.] doi: 10.1038/s41539-019-0049-x.


Olsen R, Carr VA, Daugherty AM, La Joie R, Amaral RSC, Amunts K, … Wisse LEM. 2019. Progress update from the Hippocampal Subfields Group. Alzheimer's and Dementia: Diagnosis, Assessment, and Disease Monitoring. 11: 439-449. [Epub 2019 Jun 13]. doi: 10.1016/j.dadm.2019.04.001


Arble E, * Daugherty AM, Arnetz B. (* equal contribution to first author) 2019. Differential effects of physiological arousal following acute stress on police officer performance in a simulated critical incident. Frontiers in Psychology, Psychology for Clinical Settings. 10: 759. [Epub 2019 Apr 9]. doi: 10.3389/fpsyg.2019.00759.


Daugherty AM, Hoagey DA, Kennedy KM, Rodrigue KM. 2019. Genetic predisposition for inflammation exacerbates effects of striatal iron content on cognitive switching ability in healthy aging. NeuroImage. 185: 471-78. [Epub 2018 Oct 25]. doi: 10.1016/j.neuroimage.2018.10.064.


Hect J, Daugherty AM, Hermex KM, Marusak HA, Thomason ME. 2018. Developmental variation in regional brain iron and its relation to cognitive functions in childhood. Dev Cog Neuro. 34: 18-26. [Epub 2018 May 22]. doi: 10.1016/j.dcn.2018.05.004


Arble E, Daugherty AM, Arnetz B. 2018. Models of first responder coping: Police officers as a unique population. J Stress Health. 34(5): 612-621. [Epub 2018 Jun 8]. doi: 10.1002/smi.2821


Daugherty AM, Zwilling C, Paul EJ, Sherepa N, Allen C, Kramer AF, Hillman CH, Cohen NJ, Barbey AK. 2018. Multi-modal fitness and cognitive training to enhance fluid intelligence. Intell. 66: 32-43. [Epub 2017 Nov 20]. doi: 10.1016/j.intell.2017.11.001


Bender AR, Keresztes A, Bodammer NC, Shing YL, Werkle-Bergner M, Daugherty AM, Yu Q, Kühn S, Lindenberger U, Raz N. 2018. Optimization and validation of automated hippocampal subfield segmentation across the lifespan. Hum Brain Mapp. 39(2): 916-31. [Epub 2017 Nov 23]. doi: 10.1002/hbm.23891.


Raz N, Daugherty AM. 2018. Pathways to brain aging and their modifiers: free-radical induced energetic and neural decline in senescence (FRIENDS) model. Gerontology. 64(1): 49-57. [Epub 2017 Sep 01]. doi: 10.1159/000479508


Yu Q, Daugherty AM, Brush D, Hardwick A, Lacey W, Nishimaura M, Ofen N. 2018. Socioeconomic status and hippocampal volume in children and young adults. Dev Sci. 21 (3): e12561. [Epub 2017 May 2]. doi: 10.1111/desc.12561.


Daugherty AM, Raz N. 2017. Incident risk and progression of cerebral microbleeds in healthy adults: A multi-occasion longitudinal study. Neurobiol Aging. 59: 22-29. [Epub 2017 Jul 18]. doi: 10.1016/j.neurobiolaging.2017.07.003


Rajesh A, Cooke G, Monti J, Jahn A, Daugherty AM, Cohen NJ, Kramer AF. 2017. Differences in brain architecture in remote mild traumatic brain injury. J Neurotrauma. 34 (23): 3280-87. [Epub 2017 Oct 27]. doi: 10.1089/neu.2017.5047


Awick EA, Ehlers DK, Aguinaga S, Daugherty AM, Kramer AF, McAuley E. 2017. Effects of a randomized exercise trial on physical activity, psychological distress and quality of life in older adults. Gen Hosp Psychiatry. 49:44-50. [Epub 2017 Jun 15]. doi: 10.1016/j.genhosppsych.2017.06.005


Schwarb H, Johnson CL, Daugherty AM, Hillman CH, Kramer AF, Cohen NJ, Barbey AK. 2017. Aerobic fitness effects on hippocampal viscoelasticity and relational memory performance. NeuroImage. 153: 179-188. [Epub 2017 Mar 30]. doi: 10.1016/j.neuroimage.2017.03.061


Ehlers DK, Daugherty AM, Fanning J, Awick EA, Burzynska A, Chaddock-Heyman L, Kramer AF, McAuley E. 2017. Regional brain volumes moderate, but do not mediate, the effects of group-based exercise training on reductions in loneliness in older adults. Front Aging Neurosci. 9: 110 [Epub 2017 Apr 25]. doi: 10.3389/fnagi.2017.00110


Banducci SE, Daugherty AM, Biggan JR, Cooke GE, Voss M, Noice T, Noice H, Kramer AF. 2017. Active experiencing training improves episodic memory recall in older adults. Front Aging Neurosci. 9: 133. [Epub 2017 Apr 20]. doi: 10.3389/fnagi.2017.00133.


Daugherty AM, Flinn RW, Ofen N. 2017. Hippocampal CA3-dentate gyrus volume uniquely linked to improvement in associative memory from childhood to adulthood. NeuroImage. 153: 75-85. [Epub 2017 Mar 22]. doi: 10.1016/j.neuroimage.2017.03.047


Ehlers DK, Banducci SE, Daugherty AM, Fanning J, Awick EA, Porter GC, Bursynska A, Shen S, Kramer AF, McAuley E. 2017. Effects of gait self-efficacy and lower-extremity physical function on dual-task performance in older adults. BioMed Res Int. 2017: 8570960. [Epub 2017 Feb 1]. doi: 10.1155/2017/8570960


Wisse LEM, * Daugherty AM, .... la Joie R; Hippocampal Subfields Group. (* equal contribution to first author). 2017. A harmonized segmentation protocol for hippocampal and parahippocampal subregions: why do we need one and what are the key goals? Hipp 27(1): 3-11. [Epub 2016 Nov 15]. doi: 10.1002/hipo.22671 


Sethi SK, Daugherty AM, Gadda G, Utriainen DT, Jiang J, Raz N, Haacke EM. 2017. Jugular anomalies in multiple sclerosis are associated with increased collateral venous flow. AJNR. 38 (8): 1617-1622. [Epub 2017 May 25]. doi:10.3174/ajnr.A5219.


Raz N, Daugherty AM, Sethi SK, Arshad M, Haacke EM. 2017. Age differences in arterial and venous extra-cerebral blood flow in healthy adults: Contributions of vascular risk factors and genetic variants. Brain Struct Funct. 222 (6): 2641-53. [Epub 2017 Jan 24]. doi: 10.1007/s00429-016-1362-2.


Daugherty AM, Raz N. 2017. A virtual water maze revisited: Two-year changes in navigation performance and their neural correlates in healthy adults. NeuroImage 146: 492-506. [Epub 2016 Sep 19]. doi: 10.1016/j.neuroimage.2016.09.044


Daugherty AM, Bender AR, Raz N, Ofen N. 2016. Age differences in hippocampal subfield volumes from childhood to late adulthood. Hipp 26 (2): 220-8.  doi: 10.1002/hipo.22517. [Epub 2015 Sep 4].


Daugherty AM, Raz N. 2016. Accumulation of iron in the putamen predicts its shrinkage in healthy older adults: A multi-occasion longitudinal study. NeuroImage 128: 11-20. [Epub 2015 Dec 30]. doi: 10.1016/j.neuroimage.2015.12.045


Persson N, Ghisletta P, Dahle CL, Bender AR, Yang Y, Yuan P, Daugherty AM, Raz N. 2016. Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factors. NeuroImage 126:15-26. [Epub 2015 Nov 14]. doi:10.1016/j.neuroimage.2015.11.028


Daugherty AM, Bender AR, Yuan P, Raz N. 2016. Changes in search path complexity and length during learning of a virtual water maze: Age differences and differential associations with hippocampal subfield volumes. Cer Cor 26 (6): 2391-401. [Epub 2015 Apr 1]. doi: 10.1093/cercor/bhv061


Daugherty AM, Raz N. 2015. Appraising the role of iron in brain aging and cognition: promises and limitations of MRI methods. Neuropsychol Rev 25 (3): 272-87. [Epub 2015 Aug 7]. doi: 10.1007/s11065-015-9292-y


Daugherty AM, Haacke EM, Raz N. 2015. Striatal iron content predicts its shrinkage and changes in verbal working memory after two years in healthy adults. J Neurosci. 35 (17): 6731-43. doi:10.1523/JNEUROSCI.4717-14.2015.


Daugherty AM, Ofen, N. 2015. That's a good one! Belief in efficacy of mnemonic strategies contributes to age-related increase in associative memory. J Exp Child Psychol. 136: 17-29. [Epub 2015 Apr 5]. doi: 10.1016/j.jecp.2015.02.008


Daugherty AM, Yu Q, Flinn R, Ofen N. 2015. A reliable and valid method for manual demarcation of hippocampal head, body and tail. Int J Dev Neurosci. 41: 115-22. [Epub 2015 Feb 7]. doi: 10.1016/j.ijdevneu.2015.02.001


Sethi SK, Utriainen D, Daugherty AM, Feng W, Hewett JJ, Raz N, Haacke EM. 2015. Jugular venous flow abnormalities in multiple sclerosis patients compared to normal controls. J Neuroimaging. 25 (4): 600-7. [Epub 2014 Oct 15]. doi: 10.1111/jon.12183.


Raz N, Daugherty AM, Bender AR, Dahle CL, Land S. 2015. Volume of the hippocampal subfields in healthy adults: Differential associations with age and a pro-inflammatory genetic variant. Brain Struct Funct. 220 (5): 2663-74. [Epub 2014 Jun 20]. doi: 10.1007/s00429-014-0817-6.


Daugherty AM, Yuan P, Dahle CL, Bender AR, Yang Y, Raz N. 2015. Path complexity in virtual water maze navigation: Differential associations with age, sex, and regional brain volume. Cer Cor. 25 (9): 3122-31. [Epub 2104 May 23]. doi: 10.1093/cercor/bhu107.


Yushkevich P, Amaral RS, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren AC, Carr VA, Chakravarty MM, Chetelat G, Daugherty AM … Zenieh MM. 2015. Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol. NeuroImage 111: 526-541. [Epub 2015 Jan 14]. doi: 10.1016/j.neuroimage.2015.01.004


Persson N, Ghisletta P, Dahle CL, Bender AR, Yang Y, Yuan P, Daugherty AM, Raz N. 2014. Regional brain shrinkage over two years: Individual differences and effects of pro-inflammatory genetic polymorphisms. NeuroImage 103: 334-48. [Epub 2014 Sep 28]. doi: 10.1016/j.neuroimage.2014.09.042


Adamo DE, Daugherty AM, Raz N. 2014. Grasp force matching and brain iron content estimated in vivo in older women. Brain Imaging Behav. 8 (4): 579-87. doi: 10.1007/s11682-013-9284-6.


Yuan P, Daugherty AM, Raz N. 2014. Turning bias in virtual spatial navigation: Age-related differences and neuroanatomical correlates. Biol Psychol. 96: 8-19. [Epub 2013 Nov 2]. doi: 10.1016/j.biopsycho.2013.10.009


Bender AR, Daugherty AM, Raz N. 2013. Vascular risk moderates associations between hippocampal subfield volumes and memory. J Cogn Neuro. 25 (11): 1851-62. [Epub 2013 Jun 14]. doi: 10.1162/jocn_a_00435.


Daugherty A, Raz N. 2013. Age-related differences in iron content of subcortical nuclei observed in vivo: A meta-analysis. NeuroImage. 70: 113-21. [Epub 2012 Dec 28]. doi:10.1016/j.neuroimage.2012.12.040.


Rodrigue KM, Daugherty AM, Haacke EM, Raz N. 2013. The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory. Cer Cor. 23 (7): 1533-41. [Epub 2012 May 29]. doi: 10.1093/cercor/bhs139.